Analgesic and Anti-Inﬂammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia.
Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20.
Quantification of BNN27, a novel neuroprotective 17-spiroepoxy dehydroepiandrosterone derivative in the blood and retina of rodents, after single intraperitoneal administration.
The beneficial role of the synthetic microneurotrophin BNN20 in a focal demyelination model.
The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts cognitive deficits induced by the D1/D2 dopaminergic receptor agonist apomorphine in rats.
Psychoactive properties of BNN27, a novel neurosteroid derivate, in male and female rats.
Anti-neuroinflammatory, protective effects of the synthetic microneurotrophin BNN-20 in the advanced dopaminergic neurodegeneration of "weaver" mice.
Neurosteroids as regulators of neuroinflammation.
Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina.
The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts behavioural deficits induced by the NMDA receptor antagonist ketamine in rats.
The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Rats With Streptozotocin-Induced Diabetes.
DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.
The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone- induced death, through the NGF receptor TrkA.
BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor.
The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats.
Synthetic microneurotrophins in therapeutics of neurodegeneration.
BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.
MicroNeurotrophins Improve Survival in Motor Neuron- Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.
Effects of novel synthetic microneurotrophins in diabetic retinopathy.
Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors.
Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.
Neurosteroids and microneurotrophins signal through NGF receptors to induce prosurvival signaling in neuronal cells.
The neurosteroid dehydroepiandrosterone (DHEA) protects the retina from AMPA-induced excitotoxicity: NGF TrkA receptor involvement.
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.
Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity.
Dehydroepiandrosterone protects human keratinocytes against apoptosis through membrane binding sites.
Neurosteroid dehydroepiandrosterone exerts anti-apoptotic effects by membrane-mediated, integrated genomic and non-genomic pro-survival signaling pathways.
Neurosteroids as modulators of neurogenesis and neuronal survival.
Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging.
G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone.
Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization.
Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation.
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins.